Undisputed heavyweight champion Tom Aspinall returns to defend his title against former interim champion Ciryl Gane in a high-stakes clash that could redefine the division. Aspinall arrives on a dominant three-fight win streak, including a first-round knockout of Curtis Blaydes at UFC 304, and enters Abu Dhabi as one of the sport’s most explosive and well-rounded champions. Gane, undefeated since his loss to Jon Jones, brings elite technical striking and is determined to reclaim his place at the top in what could be his final opportunity to capture gold. In the co-main event, Mackenzie Dern faces Virna Jandiroba for the vacant Strawweight Championship. This marks the first title shot of Dern’s career, while Jandiroba looks to secure a historic win for Brazil and cement her legacy in one of the UFC’s most competitive divisions. The main card will also feature heavyweight contenders Alexander Volkov vs. Jailton Almeida, a bantamweight showcase between Umar Nurmagomedov and Mario Bautista, and a light heavyweight collision between Aleksandar Rakic and Azamat Murzakanov, adding depth and global star power to the night. The prelims will spotlight rising international names and regional fan favourites, including Ikram Aliskerov, Abdul-Karim Al-Selwady, Nathaniel Wood, and Hamdy Abdelwahab, further reflecting the Middle East’s growing influence in the global MMA landscape. Their presence reinforces Abu Dhabi’s status not only as a host city, but as a platform for both established champions and emerging talent. UFC 321 represents another defining moment for Abu Dhabi, positioning it at the centre of the global MMA stage and as a key destination for major title fights, elite competition, and a passionate regional fanbase.